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    octr-1 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 184469, updated on 9-Dec-2024

    Summary

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    Official Symbol
    octr-1
    Official Full Name
    G-protein coupled receptors family 1 profile domain-containing protein
    Primary source
    WormBase:WBGene00006411
    Locus tag
    CELE_F14D12.6
    See related
    AllianceGenome:WB:WBGene00006411
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables octopamine receptor activity. Involved in negative regulation of innate immune response; octopamine signaling pathway; and regulation of IRE1-mediated unfolded protein response. Predicted to be located in membrane and synapse. Predicted to be active in dendrite and plasma membrane. Is expressed in intestine; nervous system; reproductive system; tail; and in male. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; artery disease (multiple); attention deficit hyperactivity disorder; nicotine dependence; and type 2 diabetes mellitus. Orthologous to several human genes including ADRA2A (adrenoceptor alpha 2A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See octr-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (5609110..5611255, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PH domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Arginase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans OCTR-1 and Human Alpha-2A Adrenergic Receptors are Methylated within the Third Intracellular Loop by Human PRMT5 in vitro. Bowitch A, et al. MicroPubl Biol, 2022. PMID 35622502, Free PMC Article
    2. Octopaminergic Signaling Mediates Neural Regulation of Innate Immunity in Caenorhabditis elegans. Sellegounder D, et al. mBio, 2018 Oct 9. PMID 30301853, Free PMC Article
    3. Distinct Roles of Sensory Neurons in Mediating Pathogen Avoidance and Neuropeptide-Dependent Immune Regulation. Cao X, et al. Cell Rep, 2017 Nov 7. PMID 29117551, Free PMC Article
    4. Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation. Sun J, et al. EMBO Rep, 2012 Sep. PMID 22791024, Free PMC Article
    5. Neuronal GPCR OCTR-1 regulates innate immunity by controlling protein synthesis in Caenorhabditis elegans. Liu Y, et al. Sci Rep, 2016 Nov 11. PMID 27833098, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OCTR-1 inhibits specific protein synthesis factors such as ribosomal protein RPS-1 and translation initiation factor EIF-3.J to reduce infection-triggered protein synthesis and the unfolded protein response.
      Title: Neuronal GPCR OCTR-1 regulates innate immunity by controlling protein synthesis in Caenorhabditis elegans.
    2. found OCTR-1, putative octopamine G protein-coupled catecholamine receptor, functioned in sensory neurons (ASH and ASI) to suppress innate immune responses by down-regulating expression of noncanonical UPR genes pqn/abu in nonneuronal tissues
      Title: Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes.
    3. Temporal regulation of the canonical XBP-1 pathway involved in the unfolded protein response by the neurally expressed receptor OCTR-1.
      Title: Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables octopamine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in octopamine signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of IRE1-mediated unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein
    NP_001024568.1
    • Confirmed by transcript evidence
    NP_001024569.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5609110..5611255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029397.4 → NP_001024568.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024568.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JP62
      Conserved Domains (1) summary
      cd15059
      Location:22 → 387
      7tmA_alpha2_AR; alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001029398.4 → NP_001024569.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JP61
      Conserved Domains (1) summary
      cd15059
      Location:22 → 389
      7tmA_alpha2_AR; alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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