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    cdr-1 CaDmium Responsive [ Caenorhabditis elegans ]

    Gene ID: 180064, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdr-1
    Official Full Name
    CaDmium Responsive
    Primary source
    WormBase:WBGene00000412
    Locus tag
    CELE_F35E8.11
    See related
    AllianceGenome:WB:WBGene00000412
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in stress response to cadmium ion. Located in lysosome. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cdr-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (15921309..15922820)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ShKT domain-containing protein Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA Neighboring gene Nuclear hormone receptor family member nhr-108 Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA Neighboring gene Paired zinc finger protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a novel, cadmium-inducible gene from the nematode Caenorhabditis elegans. A new gene that contributes to the resistance to cadmium toxicity. Liao VH, et al. J Biol Chem, 2002 Nov 1. PMID 12189149
    2. Role of MTL-1, MTL-2, and CDR-1 in mediating cadmium sensitivity in Caenorhabditis elegans. Hall J, et al. Toxicol Sci, 2012 Aug. PMID 22552775, Free PMC Article
    3. Molecular characterization of two homologs of the Caenorhabditis elegans cadmium-responsive gene cdr-1: cdr-4 and cdr-6. Dong J, et al. J Mol Biol, 2008 Feb 22. PMID 18177893, Free PMC Article
    4. Identification and characterization of a family of Caenorhabditis elegans genes that is homologous to the cadmium-responsive gene cdr-1. Dong J, et al. Biochim Biophys Acta, 2005 Jan 21. PMID 15652154
    5. Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons. Prahlad V, et al. Science, 2008 May 9. PMID 18467592, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. isolation and characterization of the full-length mRNA and the gene, designated cdr-1 (cadmium-responsive gene family)
      Title: Molecular characterization of a novel, cadmium-inducible gene from the nematode Caenorhabditis elegans. A new gene that contributes to the resistance to cadmium toxicity.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in stress response to cadmium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in stress response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CaDmium Responsive
    NP_506986.1
    • Product from WormBase gene class cdr;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15921309..15922820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074585.9 → NP_506986.1  CaDmium Responsive [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506986.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE89
      Conserved Domains (3) summary
      cd03193
      Location:199 → 267
      GST_C_Metaxin; C-terminal, alpha helical domain of Metaxin and related proteins
      COG0625
      Location:204 → 267
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03080
      Location:44 → 117
      GST_N_Metaxin_like; GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It ...
    Nucleotide Protein
    Heading Accession and Version

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