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    nol-56 Nucleolar protein 56 [ Caenorhabditis elegans ]

    Gene ID: 179442, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nol-56
    Official Full Name
    Nucleolar protein 56
    Primary source
    WormBase:WBGene00010627
    Locus tag
    CELE_K07C5.4
    See related
    AllianceGenome:WB:WBGene00010627
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable snoRNA binding activity. Predicted to be involved in ribosome biogenesis. Predicted to be located in nucleolus. Predicted to be part of box C/D methylation guide snoRNP complex and small-subunit processome. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 36. Orthologous to human NOP56 (NOP56 ribonucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nol-56 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (10350466..10352978, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Pre-mRNA-splicing factor SLU7 Neighboring gene Epoxide hydrolase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microarray analysis of ncRNA expression patterns in Caenorhabditis elegans after RNAi against snoRNA associated proteins. Aftab MN, et al. BMC Genomics, 2008 Jun 11. PMID 18547420, Free PMC Article
    2. The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging. Sheaffer KL, et al. Curr Biol, 2008 Sep 23. PMID 18804378, Free PMC Article
    3. Autofluorescence as a noninvasive biomarker of senescence and advanced glycation end products in Caenorhabditis elegans. Komura T, et al. NPJ Aging Mech Dis, 2021 Jun 7. PMID 34099724, Free PMC Article
    4. A ZTF-7/RPS-2 complex mediates the cold-warm response in C. elegans. Xu T, et al. PLoS Genet, 2023 Feb. PMID 36763670, Free PMC Article
    5. Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs. Hayes GD, et al. Cold Spring Harb Symp Quant Biol, 2006. PMID 17381276

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of box C/D methylation guide snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box C/D methylation guide snoRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nucleolar protein 56
    NP_505660.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10350466..10352978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073259.11 → NP_505660.1  Nucleolar protein 56 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505660.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21276
      Conserved Domains (3) summary
      smart00931
      Location:171 → 220
      NOSIC; NOSIC (NUC001) domain
      pfam01798
      Location:177 → 412
      Nop; snoRNA binding domain, fibrillarin
      pfam08156
      Location:7 → 72
      NOP5NT; NOP5NT (NUC127) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21276.1

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