lsd-1 Lysine-specific histone demethylase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lsd-1
Official Full Name: Lysine-specific histone demethylase
Primary source: WormBase:WBGene00011615
Locus tag: CELE_T08D10.2
See related: AllianceGenome:WB:WBGene00011615
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable FAD-dependent H3K4me/H3K4me3 demethylase activity; chromatin binding activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in epigenetic regulation of gene expression. Predicted to be located in chromatin. Predicted to be active in nucleus. Orthologous to human KDM1A (lysine demethylase 1A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lsd-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 9

Sequence:: Chromosome: X; NC_003284.9 (11948844..11951893)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This suggests that histone H3 lysine 4 dimethylation(H3K4me2)can serve as a stable epigenetic memory, and erasure of H3K4me2 by LSD/KDM1 in the germline prevents the inappropriate transmission of this epigenetic memory from one generation to the next.
Title: A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T08D10.2 (e-PCR)
- UniSTS:307975

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables FAD-dependent H3K4me/H3K4me3 demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables FAD-dependent H3K4me/H3K4me3 demethylase activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Lysine-specific histone demethylase

NP_510000.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

11948844..11951893

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077599.7 → NP_510000.2 Lysine-specific histone demethylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510000.2

Status: REVIEWED

UniProtKB/TrEMBL

Q22343

Conserved Domains (2) summary

pfam01593
Location:191 → 706

Amino_oxidase; Flavin containing amine oxidoreductase

pfam04433
Location:80 → 158

SWIRM; SWIRM domain