zyx-1 Zyxin [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: zyx-1
Official Full Name: Zyxin
Primary source: WormBase:WBGene00006999
Locus tag: CELE_F42G4.3
See related: AllianceGenome:WB:WBGene00006999
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DEAD/H-box RNA helicase binding activity. Involved in maintenance of synapse structure. Acts upstream of or within with a positive effect on smooth muscle contraction. Located in M band; nucleus; and striated muscle dense body. Is expressed in several structures, including intestine; muscle cell; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to several human genes including LPP (LIM domain containing preferred translocation partner in lipoma) and TRIP6 (thyroid hormone receptor interactor 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See zyx-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 12

Sequence:: Chromosome: II; NC_003280.10 (13057152..13071513)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

azyx-1 is a new gene that overlaps with zyxin and affects its translation in C. elegans, impacting muscular integrity and locomotion.
Title: azyx-1 is a new gene that overlaps with zyxin and affects its translation in C. elegans, impacting muscular integrity and locomotion.
ZYX-1 is a conserved LIM domain-containing focal adhesion protein that regulates synapse maintenance in Caenorhabditis elegans
Title: The conserved LIM domain-containing focal adhesion protein ZYX-1 regulates synapse maintenance in Caenorhabditis elegans.
The zyx-1 gene encodes two different isoforms, ZYX-1a and ZYX-1b, which exhibit different roles in dystrophin-dependent muscle degeneration in C. elegans
Title: ZYX-1, the unique zyxin protein of Caenorhabditis elegans, is involved in dystrophin-dependent muscle degeneration.
DYC-1 interacts with ZYX-1, the homologue of the vertebrate focal adhesion LIM domain protein zyxin.
Title: DYC-1, a protein functionally linked to dystrophin in Caenorhabditis elegans is associated with the dense body, where it interacts with the muscle LIM domain protein ZYX-1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F42G4.3 (e-PCR)
- UniSTS:314311

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DEAD/H-box RNA helicase binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in maintenance of synapse structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in M band	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in striated muscle dense body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Zyxin

NP_001254364.1

Confirmed by transcript evidence

NP_001254365.1

Confirmed by transcript evidence

NP_001254366.1

Confirmed by transcript evidence

NP_496776.1

Confirmed by transcript evidence

NP_496777.2

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

13057152..13071513

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001267435.4 → NP_001254364.1 Zyxin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254364.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U3F4

Conserved Domains (1) summary

cl02475
Location:531 → 595

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_064375.10 → NP_496776.1 Zyxin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496776.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L2F5, H2L2F6, H2L2F7, Q9U3F4, Q9U3F5

Conserved Domains (2) summary

cd09357
Location:531 → 593

LIM3_Zyxin_like; The third LIM domain of Zyxin-like family

cl02475
Location:471 → 530

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001267436.3 → NP_001254365.1 Zyxin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254365.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U3F4

Conserved Domains (2) summary

cd09357
Location:265 → 327

LIM3_Zyxin_like; The third LIM domain of Zyxin-like family

cl02475
Location:205 → 264

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001267437.3 → NP_001254366.1 Zyxin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254366.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U3F4

Conserved Domains (2) summary

cd09357
Location:173 → 235

LIM3_Zyxin_like; The third LIM domain of Zyxin-like family

cl02475
Location:113 → 172

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_064376.6 → NP_496777.2 Zyxin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496777.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U3F4

Conserved Domains (2) summary

cd09357
Location:128 → 190

LIM3_Zyxin_like; The third LIM domain of Zyxin-like family

cl02475
Location:68 → 127

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers