tdo-2 Tryptophan 2,3-dioxygenase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tdo-2
Official Full Name: Tryptophan 2,3-dioxygenase
Primary source: WormBase:WBGene00016201
Locus tag: CELE_C28H8.11
See related: AllianceGenome:WB:WBGene00016201
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable heme binding activity and tryptophan 2,3-dioxygenase activity. Predicted to be involved in tryptophan catabolic process to acetyl-CoA. Is expressed in body wall musculature and hypodermis. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tdo-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (5917628..5919955, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of TDO-2's enzymatic activity in three amino acids deletion mutants was accompanied by an increase in motility during aging and a prolonged lifespan, which is in line with the previously observed phenotypes induced by a knockdown of the full enzyme.
Title: Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase.
We identify tryptophan 2,3-dioxygenase (tdo-2), the first enzyme in the kynurenine pathway of tryptophan degradation, as a metabolic regulator of age-related alpha-synuclein toxicity.
Title: Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C28H8.11 (e-PCR)
- UniSTS:306748

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables tryptophan 2,3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tryptophan 2,3-dioxygenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tryptophan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process to acetyl-CoA	IBA Inferred from Biological aspect of Ancestor more info
involved_in tryptophan catabolic process to kynurenine	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Tryptophan 2,3-dioxygenase

NP_001040847.1

Confirmed by transcript evidence

NP_498284.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5917628..5919955 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065883.5 → NP_498284.1 Tryptophan 2,3-dioxygenase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498284.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09474, Q27GU8, Q8I7L6

Conserved Domains (1) summary

pfam03301
Location:22 → 371

Trp_dioxygenase; Tryptophan 2,3-dioxygenase
NM_001047382.6 → NP_001040847.1 Tryptophan 2,3-dioxygenase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040847.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09474

Conserved Domains (1) summary

cl03994
Location:1 → 80

Trp_dioxygenase; Tryptophan 2,3-dioxygenase