aex-2 G-protein coupled receptor aex-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: aex-2
Official Full Name: G-protein coupled receptor aex-2
Primary source: WormBase:WBGene00000085
Locus tag: CELE_T14B1.2
See related: AllianceGenome:WB:WBGene00000085
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable neuropeptide receptor activity. Involved in several processes, including neuropeptide signaling pathway; positive regulation of digestive system process; and positive regulation of triglyceride transport. Predicted to be located in cilium and plasma membrane. Is expressed in alimentary muscle; head mesodermal cell; intestine; nervous system; and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See aex-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (9650999..9653116, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A screen of neuropeptide genes identified and validated nlp-40 and its receptor aex-2 as a key regulator of anoxic survival in developing worms.
Title: Neuropeptide signaling regulates the susceptibility of developing C. elegans to anoxia.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T14B1.2 (e-PCR)
- UniSTS:318489

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	IC Inferred by Curator more info	PubMed
enables neuropeptide receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lipid transport involved in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intestinal lipid absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of triglyceride transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of defecation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein coupled receptor aex-2

NP_509626.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

9650999..9653116 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077225.8 → NP_509626.2 G-protein coupled receptor aex-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509626.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECD9

Conserved Domains (1) summary

pfam00001
Location:37 → 272

7tm_1; 7 transmembrane receptor (rhodopsin family)