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    pbo-5 Proton-gated ion channel subunit pbo-5 [ Caenorhabditis elegans ]

    Gene ID: 189903, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pbo-5
    Official Full Name
    Proton-gated ion channel subunit pbo-5
    Primary source
    WormBase:WBGene00012857
    Locus tag
    CELE_Y44A6E.1
    See related
    AllianceGenome:WB:WBGene00012857
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables extracellular ligand-gated monoatomic ion channel activity. Involved in several processes, including defecation; lipid transport involved in lipid storage; and positive regulation of intestinal lipid absorption. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in RIFL; RIFR; RIS; and body wall musculature. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pbo-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (20915486..20922732)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene putative tubulin polyglutamylase ttll-9 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protons act as a transmitter for muscle contraction in C. elegans. Beg AA, et al. Cell, 2008 Jan 11. PMID 18191228, Free PMC Article
    2. Aberrant fat metabolism in Caenorhabditis elegans mutants with defects in the defecation motor program. Sheng M, et al. PLoS One, 2015. PMID 25849533, Free PMC Article
    3. Neuropeptide signaling: from the gut. Zhao B, et al. Curr Biol, 2013 Jun 3. PMID 23743414
    4. The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit. Culetto E, et al. J Biol Chem, 2004 Oct 8. PMID 15280391
    5. An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction. Sando SR, et al. Elife, 2021 Jul 2. PMID 34212858, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport involved in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of intestinal lipid absorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of striated muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Proton-gated ion channel subunit pbo-5
    NP_001024239.1
    • Confirmed by transcript evidence
    NP_001024240.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20915486..20922732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029069.7 → NP_001024240.1  Proton-gated ion channel subunit pbo-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024240.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECR4, G5ECT0
      Conserved Domains (2) summary
      pfam02931
      Location:68 → 272
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:306 → 364
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_001029068.5 → NP_001024239.1  Proton-gated ion channel subunit pbo-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024239.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECT0
      Conserved Domains (2) summary
      pfam02931
      Location:68 → 267
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:301 → 359
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ECT0.1

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