lin-48 Transcription factor ovo-like homolog lin-48 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lin-48
Official Full Name: Transcription factor ovo-like homolog lin-48
Primary source: WormBase:WBGene00003033
Locus tag: CELE_F34D10.5
See related: AllianceGenome:WB:WBGene00003033
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including hindgut morphogenesis; nematode male tail tip morphogenesis; and response to salt stress. Located in nucleus. Is expressed in ciliated neurons; interfacial epithelial cell; intestine; labial sensillum; and tail. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Orthologous to several human genes including OVOL1 (ovo like transcriptional repressor 1) and OVOL2 (ovo like zinc finger 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lin-48 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (3745438..3747572)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results show that innovation can be achieved by altered expression of a transcription factor without coevolution of all target genes
Title: Evolutionary innovation of the excretory system in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F34D10.5 (e-PCR)
- UniSTS:310106

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transcription factor ovo-like homolog lin-48

NP_497759.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3745438..3747572

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065358.5 → NP_497759.1 Transcription factor ovo-like homolog lin-48 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497759.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EDU6

Conserved Domains (2) summary

sd00017
Location:135 → 155

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:175 → 200

zf-H2C2_2; Zinc-finger double domain