ces-1 C2H2-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ces-1
Official Full Name: C2H2-type domain-containing protein
Primary source: WormBase:WBGene00000468
Locus tag: CELE_F43G9.11
See related: AllianceGenome:WB:WBGene00000468
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of programmed cell death and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in head ganglion and head neurons. Orthologous to human SCRT1 (scratch family transcriptional repressor 1) and SCRT2 (scratch family transcriptional repressor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ces-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (8633897..8636169)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Snail transcription factor CES-1 regulates glutamatergic behavior in C. elegans.
Title: The Snail transcription factor CES-1 regulates glutamatergic behavior in C. elegans.
CES-1 Snail represses pig-1 MELK transcription in the neurosecretory motor neuron neuroblast lineage.
Title: Caenorhabditis elegans CES-1 Snail Represses pig-1 MELK Expression To Control Asymmetric Cell Division.
we provide evidence that dnj-11 MIDA1 not only regulate CES-1 activity in the context of cell polarity and apoptosis but also in the context of cell cycle progression.
Title: Coordination of cell proliferation and cell fate determination by CES-1 snail.
data indicates that there are at least two types of CES-1 target genes.
Title: The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F43G9.11 (e-PCR)
- UniSTS:319346

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: C2H2-type domain-containing protein

NP_492338.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8633897..8636169

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059937.3 → NP_492338.1 C2H2-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492338.1

Status: REVIEWED

UniProtKB/TrEMBL

G5ECN8

Conserved Domains (3) summary

sd00017
Location:193 → 213

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:219 → 241

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:233 → 257

zf-H2C2_2; Zinc-finger double domain