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    srdf-2.1 3-oxo-5-alpha-steroid 4-dehydrogenase [ Caenorhabditis elegans ]

    Gene ID: 184699, updated on 9-Dec-2024

    Summary

    Official Symbol
    srdf-2.1
    Official Full Name
    3-oxo-5-alpha-steroid 4-dehydrogenase
    Primary source
    WormBase:WBGene00008959
    Locus tag
    CELE_F19H6.4
    See related
    AllianceGenome:WB:WBGene00008959
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3-oxo-5-alpha-steroid 4-dehydrogenase activity. Predicted to be involved in steroid biosynthetic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in hypospadias; prostate cancer; and prostatic hypertrophy. Orthologous to several human genes including SRD5A2 (steroid 5 alpha-reductase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See srdf-2.1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (12365688..12367255)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Nematode Specific Peptide family, group C Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene tRNA-Glu Neighboring gene BRCT domain-containing protein Neighboring gene ncRNA

    General gene information

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in androgen biosynthetic process  
    involved_in lipid metabolic process  
    involved_in sex differentiation  
    involved_in steroid biosynthetic process  
    involved_in steroid metabolic process  
    Component Evidence Code Pubs
    located_in membrane  

    General protein information

    Preferred Names
    3-oxo-5-alpha-steroid 4-dehydrogenase
    NP_510077.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      12365688..12367255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077676.4NP_510077.1  3-oxo-5-alpha-steroid 4-dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510077.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19605
      Conserved Domains (1) summary
      pfam02544
      Location:97243
      Steroid_dh; 3-oxo-5-alpha-steroid 4-dehydrogenase
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