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    cdh-1 Cadherin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 187783, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdh-1
    Official Full Name
    Cadherin domain-containing protein
    Primary source
    WormBase:WBGene00019994
    Locus tag
    CELE_R10F2.1
    See related
    AllianceGenome:WB:WBGene00019994
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Orthologous to human DCHS1 (dachsous cadherin-related 1) and DCHS2 (dachsous cadherin-related 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cdh-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    20
    Sequence:
    Chromosome: III; NC_003281.10 (2910906..2935961)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Glycine Rich Secreted Protein Neighboring gene RRP12-like protein Neighboring gene Cytochrome P450 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tyrosine-protein phosphatase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis. Dufourcq P, et al. Mol Cell Biol, 2002 May. PMID 11940660, Free PMC Article
    2. The cadherin superfamily. Pettitt J. WormBook, 2005 Dec 29. PMID 18050421, Free PMC Article
    3. Wnt ligands regulate the asymmetric divisions of neuronal progenitors in C. elegans embryos. Kaur S, et al. Development, 2020 Apr 6. PMID 32156756, Free PMC Article
    4. Cell adhesion receptors in C. elegans. Cox EA, et al. J Cell Sci, 2004 Apr 15. PMID 15090591
    5. Cadherin superfamily proteins in Caenorhabditis elegans and Drosophila melanogaster. Hill E, et al. J Mol Biol, 2001 Feb 2. PMID 11162110

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cadherin domain-containing protein
    NP_497641.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2910906..2935961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065240.3 → NP_497641.2  Cadherin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497641.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5F4W0
      Conserved Domains (1) summary
      cd11304
      Location:947 → 1041
      Cadherin_repeat; Cadherin tandem repeat domain
    Nucleotide Protein
    Heading Accession and Version

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