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    npr-10 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183747, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npr-10
    Official Full Name
    G-protein coupled receptors family 1 profile domain-containing protein
    Primary source
    WormBase:WBGene00008278
    Locus tag
    CELE_C53C7.1
    See related
    AllianceGenome:WB:WBGene00008278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable neuropeptide binding activity and neuropeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Is expressed in RMEV; ciliated neurons; and ganglia. Human ortholog(s) of this gene implicated in hypertension; lipid metabolism disorder; and obesity. Orthologous to several human genes including PRLHR (prolactin releasing hormone receptor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npr-10 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (13018393..13032710, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct neuropeptide-receptor modules regulate a sex-specific behavioral response to a pheromone. Reilly DK, et al. Commun Biol, 2021 Aug 31. PMID 34465863, Free PMC Article
    2. Comparative and Evolutionary Aspects of Gonadotropin-Inhibitory Hormone and FMRFamide-Like Peptide Systems. Ubuka T, et al. Front Neurosci, 2018. PMID 30405335, Free PMC Article
    3. The neuropeptidergic connectome of C. elegans. Ripoll-Sánchez L, et al. Neuron, 2023 Nov 15. PMID 37935195, Free PMC Article
    4. System-wide mapping of peptide-GPCR interactions in C. elegans. Beets I, et al. Cell Rep, 2023 Sep 26. PMID 37656621, Free PMC Article
    5. A database of Caenorhabditis elegans behavioral phenotypes. Yemini E, et al. Nat Methods, 2013 Sep. PMID 23852451, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct neuropeptide-receptor modules regulate a sex-specific behavioral response to a pheromone.
      Title: Distinct neuropeptide-receptor modules regulate a sex-specific behavioral response to a pheromone.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide Y receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein
    NP_001024487.1
    • Confirmed by transcript evidence
    NP_001024488.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13018393..13032710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029316.4 → NP_001024487.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024487.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XXU4
      Conserved Domains (1) summary
      cd15203
      Location:29 → 318
      7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001029317.3 → NP_001024488.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024488.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6EUU1
      Conserved Domains (1) summary
      cd15203
      Location:29 → 318
      7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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