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    egl-43 Zinc finger protein egl-43 [ Caenorhabditis elegans ]

    Gene ID: 174552, updated on 9-Dec-2024

    Summary

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    Official Symbol
    egl-43
    Official Full Name
    Zinc finger protein egl-43
    Primary source
    WormBase:WBGene00001207
    Locus tag
    CELE_R53.3
    See related
    AllianceGenome:WB:WBGene00001207
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription factor activity. Involved in several processes, including regulation of cell fate specification; regulation of neuron differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including MSaaaa; MSaaap; gonad; neurons; and somatic gonad precursor. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1LL and myeloid neoplasm. Orthologous to human MECOM (MDS1 and EVI1 complex locus) and PRDM16 (PR/SET domain 16). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See egl-43 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (9955185..9962995)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene PUL domain-containing protein;Ubiquitin fusion degradation protein 3 homolog Neighboring gene FAD synthase;Molybdenum cofactor biosynthesis protein-like region Neighboring gene Thymidylate kinase Neighboring gene ncRNA Neighboring gene Putative ATP synthase subunit f, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Migrations of the Caenorhabditis elegans HSNs are regulated by egl-43, a gene encoding two zinc finger proteins. Garriga G, et al. Genes Dev, 1993 Nov. PMID 8224840
    2. Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans. Rimann I, et al. Dev Biol, 2007 Aug 1. PMID 17573066
    3. Cell interactions and patterned intercalations shape and link epithelial tubes in C. elegans. Rasmussen JP, et al. PLoS Genet, 2013. PMID 24039608, Free PMC Article
    4. The Caenorhabditis elegans homolog of the Evi1 proto-oncogene, egl-43, coordinates G1 cell cycle arrest with pro-invasive gene expression during anchor cell invasion. Deng T, et al. PLoS Genet, 2020 Mar. PMID 32203506, Free PMC Article
    5. Reevaluating the relationship between EGL-43 (EVI1) and LIN-12 (Notch) during C. elegans anchor cell invasion. Martinez MAQ, et al. Biol Open, 2022 Dec 15. PMID 36445013, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reevaluating the relationship between EGL-43 (EVI1) and LIN-12 (Notch) during C. elegans anchor cell invasion.
      Title: Reevaluating the relationship between EGL-43 (EVI1) and LIN-12 (Notch) during C. elegans anchor cell invasion.
    2. MIG-10 stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans.
      Title: MIG-10 (Lamellipodin) stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans.
    3. EGL-43 is required to specify the cell fates of ventral uterus cells downstream of or in parallel with LIN-12 NOTCH.
      Title: Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans.
    4. egl-43 integrates temporally distinct upstream regulatory events and helps program cell fate specification and cell invasion
      Title: C. elegans EVI1 proto-oncogene, EGL-43, is necessary for Notch-mediated cell fate specification and regulates cell invasion.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc finger protein egl-43
    NP_001022288.1
    • Confirmed by transcript evidence
    NP_001359539.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9955185..9962995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027117.6 → NP_001022288.1  Zinc finger protein egl-43 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022288.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22023, Q22024, Q26336, Q26337, Q7JM79, Q7JPS6
      Conserved Domains (4) summary
      COG5189
      Location:115 → 210
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:446 → 466
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:444 → 466
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:458 → 482
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001373787.1 → NP_001359539.1  Zinc finger protein egl-43 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      sd00017
      Location:225 → 245
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:223 → 245
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:237 → 261
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_002363.2 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22024.1

    Gene LinkOut

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