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    fut-6 Alpha-(1,3)-fucosyltransferase fut-6 [ Caenorhabditis elegans ]

    Gene ID: 188084, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fut-6
    Official Full Name
    Alpha-(1,3)-fucosyltransferase fut-6
    Primary source
    WormBase:WBGene00020222
    Locus tag
    CELE_T05A7.5
    See related
    AllianceGenome:WB:WBGene00020222
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables alpha-(1->3)-fucosyltransferase activity. Involved in fucosylation. Predicted to be located in Golgi cisterna membrane. Orthologous to human FUT7 (fucosyltransferase 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fut-6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (4653176..4655934, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Rootletin Neighboring gene Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Neighboring gene ncRNA Neighboring gene DUF38 domain-containing protein Neighboring gene Tyrosine-protein phosphatase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparisons of Caenorhabditis Fucosyltransferase Mutants Reveal a Multiplicity of Isomeric N-Glycan Structures. Yan S, et al. J Proteome Res, 2015 Dec 4. PMID 26538210, Free PMC Article
    2. Bisecting Galactose as a Feature of N-Glycans of Wild-type and Mutant Caenorhabditis elegans. Yan S, et al. Mol Cell Proteomics, 2015 Aug. PMID 26002521, Free PMC Article
    3. Plasticity of the β-trefoil protein fold in the recognition and control of invertebrate predators and parasites by a fungal defence system. Schubert M, et al. PLoS Pathog, 2012. PMID 22615566, Free PMC Article
    4. Array-assisted characterization of a fucosyltransferase required for the biosynthesis of complex core modifications of nematode N-glycans. Yan 闫石 S, et al. J Biol Chem, 2013 Jul 19. PMID 23754284, Free PMC Article
    5. Molecular cloning and characterization of the Caenorhabditis elegans alpha1,3-fucosyltransferase family. Nguyen K, et al. Glycobiology, 2007 Jun. PMID 17369288

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FUT-6 is probably the first eukaryotic glycosyltransferase whose specificity has been redefined with the aid of glycan microarrays.
      Title: Array-assisted characterization of a fucosyltransferase required for the biosynthesis of complex core modifications of nematode N-glycans.
    2. different locations and capping of fucose meant that up to 13 isomeric structures, many highly galactosylated, were determined for mutants defective in two core fucosyltransferases each (fut-1;fut-6, fut-1;fut-8, and fut-6;fut-8)
      Title: Comparisons of Caenorhabditis Fucosyltransferase Mutants Reveal a Multiplicity of Isomeric N-Glycan Structures.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-(1->3)-fucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fucosyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fucosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fucosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fucosylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in fucosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Alpha-(1,3)-fucosyltransferase fut-6
    NP_494823.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4653176..4655934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062422.9 → NP_494823.2  Alpha-(1,3)-fucosyltransferase fut-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494823.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEE1
      Conserved Domains (2) summary
      pfam00852
      Location:194 → 375
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:64 → 174
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EEE1.1

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