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    nhr-65 Nuclear hormone receptor family member nhr-65 [ Caenorhabditis elegans ]

    Gene ID: 180230, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-65
    Official Full Name
    Nuclear hormone receptor family member nhr-65
    Primary source
    WormBase:WBGene00003655
    Locus tag
    CELE_Y17D7A.3
    See related
    AllianceGenome:WB:WBGene00003655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including excretory cell; intestine; muscle cell; pharynx; and tail spike. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-65 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (18839304..18845443)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene tRNA Neighboring gene CYtochrome P450 family Neighboring gene ncRNA Neighboring gene Nuclear Hormone Receptor family Neighboring gene tryptophan--tRNA ligase Neighboring gene AAA_12 domain-containing protein;DNA2/NAM7 helicase-like C-terminal domain-containing protein;Intron-binding protein aquarius Neighboring gene Homeobox protein ceh-51

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing regulation during C. elegans development: splicing factors as regulated targets. Barberan-Soler S, et al. PLoS Genet, 2008 Feb 29. PMID 18454200, Free PMC Article
    2. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article
    3. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor family member nhr-65
    NP_001024219.1
    • Confirmed by transcript evidence
    NP_001024220.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      18839304..18845443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029049.6 → NP_001024220.1  Nuclear hormone receptor family member nhr-65 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024220.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45907
      Conserved Domains (2) summary
      pfam00104
      Location:165 → 375
      Hormone_recep; Ligand-binding domain of nuclear hormone receptor
      cl02596
      Location:13 → 75
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    2. NM_001029048.7 → NP_001024219.1  Nuclear hormone receptor family member nhr-65 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024219.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45907, Q7YTK0, Q9GTE3
      Conserved Domains (2) summary
      pfam00104
      Location:165 → 375
      Hormone_recep; Ligand-binding domain of nuclear hormone receptor
      cl02596
      Location:13 → 75
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O45907.1

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