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    msh-5 MutS protein homolog 5 [ Caenorhabditis elegans ]

    Gene ID: 178268, updated on 9-Dec-2024

    Summary

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    Official Symbol
    msh-5
    Official Full Name
    MutS protein homolog 5
    Primary source
    WormBase:WBGene00003421
    Locus tag
    CELE_F09E8.3
    See related
    AllianceGenome:WB:WBGene00003421
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable double-stranded DNA binding activity. Involved in chiasma assembly. Located in nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; primary ovarian insufficiency 13; and spermatogenic failure 74. Orthologous to human MSH5 (mutS homolog 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See msh-5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    20
    Sequence:
    Chromosome: IV; NC_003282.8 (13155233..13164054)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene Protein disulfide isomerase crld-1 Neighboring gene ncRNA Neighboring gene SCP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modeling primary ovarian insufficiency-associated loci in C. elegans identifies novel pathogenic allele of MSH5. Macaisne N, et al. J Assist Reprod Genet, 2022 Jun. PMID 35437714, Free PMC Article
    2. Crossing over during Caenorhabditis elegans meiosis requires a conserved MutS-based pathway that is partially dispensable in budding yeast. Zalevsky J, et al. Genetics, 1999 Nov. PMID 10545458, Free PMC Article
    3. Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutSγ complex. Haversat J, et al. Proc Natl Acad Sci U S A, 2022 May 24. PMID 35576467, Free PMC Article
    4. Caenorhabditis elegans msh-5 is required for both normal and radiation-induced meiotic crossing over but not for completion of meiosis. Kelly KO, et al. Genetics, 2000 Oct. PMID 11014811, Free PMC Article
    5. Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene. Winand NJ, et al. Genomics, 1998 Oct 1. PMID 9787078

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutSgamma complex.
      Title: Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutSγ complex.
    2. Results report a specific role for IFE-2 in a conserved temperature-sensitive meiotic process that results in an increase in MSH-5 protein levels.
      Title: A C. elegans eIF4E-family member upregulates translation at elevated temperatures of mRNAs encoding MSH-5 and other meiotic crossover proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chiasma assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chiasma assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiosis I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MutS protein homolog 5
    NP_001368472.1
    • Confirmed by transcript evidence
    NP_502531.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13155233..13164054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070130.8 → NP_502531.1  MutS protein homolog 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502531.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A061AKP2, Q19272, Q9NB29
      Conserved Domains (4) summary
      cd03281
      Location:603 → 811
      ABC_MSH5_euk; ATP-binding cassette domain of eukaryotic MutS5 homolog
      smart00533
      Location:305 → 611
      MUTSd; DNA-binding domain of DNA mismatch repair MUTS family
      pfam05190
      Location:449 → 543
      MutS_IV; MutS family domain IV
      pfam05192
      Location:283 → 382
      MutS_III; MutS domain III

    2. NM_001380506.1 → NP_001368472.1  MutS protein homolog 5 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd03281
      Location:157 → 365
      ABC_MSH5_euk; ATP-binding cassette domain of eukaryotic MutS5 homolog
      pfam05190
      Location:3 → 97
      MutS_IV; MutS family domain IV
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19272.2

    Gene LinkOut

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    Chemical Information
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