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    F59E12.6 ubiquitinyl hydrolase 1 [ Caenorhabditis elegans ]

    Gene ID: 173951, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F59E12.6
    Official Full Name
    ubiquitinyl hydrolase 1
    Primary source
    WormBase:WBGene00019122
    Locus tag
    CELE_F59E12.6
    See related
    AllianceGenome:WB:WBGene00019122
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type deubiquitinase activity and proteasome binding activity. Predicted to be involved in negative regulation of ERAD pathway. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F59E12.6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (5626815..5630951, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Eukaryotic translation initiation factor 3 subunit L Neighboring gene Nuclear protein localization protein 4 homolog 2 Neighboring gene Protein kinase domain-containing protein Neighboring gene pseudo Neighboring gene Nuclear protein localization protein 4 homolog 1 Neighboring gene PBPb domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    • Curated pseudogene

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitinyl hydrolase 1
    NP_001379688.1
    • Confirmed by transcript evidence
    NP_001379689.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5626815..5630951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393078.1 → NP_001379688.1  ubiquitinyl hydrolase 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYU7
      Conserved Domains (1) summary
      pfam00443
      Location:80 → 392
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. NM_001393079.1 → NP_001379689.1  ubiquitinyl hydrolase 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86MP8
      Conserved Domains (1) summary
      pfam00443
      Location:33 → 345
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version

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