sars-1 putative serine--tRNA ligase, cytoplasmic [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sars-1
Official Full Name: putative serine--tRNA ligase, cytoplasmic
Primary source: WormBase:WBGene00005663
Locus tag: CELE_C47E12.1
See related: AllianceGenome:WB:WBGene00005663
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable serine-tRNA ligase activity and tRNA binding activity. Involved in translation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human SARS1 (seryl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sars-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (10003726..10005578)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C47E12.1 (e-PCR)
- UniSTS:321288

C47E12.2 (e-PCR)
- UniSTS:307350

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables serine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables serine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in seryl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in seryl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in seryl-tRNA aminoacylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: putative serine--tRNA ligase, cytoplasmic

NP_001379106.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10003726..10005578

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392379.1 → NP_001379106.1 putative serine--tRNA ligase, cytoplasmic [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18678

Conserved Domains (1) summary

PLN02678
Location:3 → 486

PLN02678; seryl-tRNA synthetase