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    tra-2 Sex-determining transformer protein 2 [ Caenorhabditis elegans ]

    Gene ID: 174137, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tra-2
    Official Full Name
    Sex-determining transformer protein 2
    Primary source
    WormBase:WBGene00006605
    Locus tag
    CELE_C15F1.3
    See related
    AllianceGenome:WB:WBGene00006605
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables transmembrane signaling receptor activity. Involved in several processes, including hermaphrodite germ-line sex determination; oocyte fate determination; and oocyte morphogenesis. Located in nucleus; perinuclear region of cytoplasm; and plasma membrane. Is expressed in germ line. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tra-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    24
    Sequence:
    Chromosome: II; NC_003280.10 (6955384..6965673, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Folliculin;Folliculin DENN domain-containing protein;UDENN FLCN/SMCR8-type domain-containing protein Neighboring gene ncRNA Neighboring gene Mucosa-associated lymphoid tissue lymphoma translocation protein 1 Neighboring gene Homeobox protein ceh-38;One cut domain family member Neighboring gene Translation initiation factor eIF2B subunit gamma Neighboring gene ncRNA Neighboring gene RING-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The STAR RNA binding proteins GLD-1, QKI, SAM68 and SLM-2 bind bipartite RNA motifs. Galarneau A, et al. BMC Mol Biol, 2009 May 20. PMID 19457263, Free PMC Article
    2. Rapid deadenylation and Poly(A)-dependent translational repression mediated by the Caenorhabditis elegans tra-2 3' untranslated region in Xenopus embryos. Thompson SR, et al. Mol Cell Biol, 2000 Mar. PMID 10688659, Free PMC Article
    3. Convergent evolution: regulatory lightning strikes twice. Haag ES. Curr Biol, 2009 Nov 17. PMID 19922851, Free PMC Article
    4. The STAR protein, GLD-1, is a translational regulator of sexual identity in Caenorhabditis elegans. Jan E, et al. EMBO J, 1999 Jan 4. PMID 9878068, Free PMC Article
    5. Development of the male reproductive system and sexual transformation in the nematode Caenorhabditis elegans. Klass M, et al. Dev Biol, 1976 Aug. PMID 986968

    See all (194) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tra-2 mRNA export is highly regulated and plays an important role in development by regulating the activity of tra-2 mRNA in the cytoplasm.
      Title: NXF-2, REF-1, and REF-2 affect the choice of nuclear export pathway for tra-2 mRNA in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in female gonad development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in germ-line sex determination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hermaphrodite germ-line sex determination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hermaphrodite germ-line sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hermaphrodite somatic sex determination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hermaphrodite somatic sex determination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in hermaphrodite somatic sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in oocyte fate determination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in oocyte morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in oocyte morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sex-determining transformer protein 2
    NP_001021954.1
    • Partially confirmed by transcript evidence
    NP_001367508.1
    • Confirmed by transcript evidence
    NP_495426.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6955384..6965673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063025.9 → NP_495426.1  Sex-determining transformer protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495426.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34709, Q8STA8, Q8STE2, Q8T5X5, Q8T5X6, Q8T5X7, Q8T5X8, Q8T5X9, Q8T5Y0, Q8T5Y1, Q8T5Y2, Q8T5Y3, Q8T5Y4, Q8T5Y5, Q9N5Y5
      Conserved Domains (1) summary
      cl14876
      Location:913 → 1072
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    2. NM_001381483.1 → NP_001367508.1  Sex-determining transformer protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G8JY28
      Conserved Domains (1) summary
      PRK10263
      Location:231 → 373
      PRK10263; DNA translocase FtsK; Provisional

    3. NM_001026783.6 → NP_001021954.1  Sex-determining transformer protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021954.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34709
      Conserved Domains (1) summary
      TIGR00918
      Location:63 → 160
      2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34709.1

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