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    sms-1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 [ Caenorhabditis elegans ]

    Gene ID: 178072, updated on 9-Dec-2024

    Summary

    Official Symbol
    sms-1
    Official Full Name
    Phosphatidylcholine:ceramide cholinephosphotransferase 1
    Primary source
    WormBase:WBGene00004892
    Locus tag
    CELE_H21P03.3
    See related
    AllianceGenome:WB:WBGene00004892
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Is expressed in several structures, including body wall musculature; pharyngeal cell; rectal muscle; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in calvarial doughnut lesions with bone fragility. Orthologous to several human genes including SGMS2 (sphingomyelin synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See sms-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (11482662..11498174, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene HTH cro/C1-type domain-containing protein Neighboring gene Non-structural maintenance of chromosomes element 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BPTI/Kunitz inhibitor domain-containing protein

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ceramide cholinephosphotransferase activity  
    enables ceramide cholinephosphotransferase activity PubMed 
    enables phosphotransferase activity, for other substituted phosphate groups  
    enables sphingomyelin synthase activity  
    enables sphingomyelin synthase activity  
    enables transferase activity  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process  
    involved_in sphingolipid metabolic process  
    involved_in sphingomyelin biosynthetic process  
    involved_in sphingomyelin biosynthetic process PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in Golgi membrane  
    located_in Golgi membrane  
    located_in Golgi membrane PubMed 
    is_active_in endoplasmic reticulum membrane  
    located_in membrane  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    Phosphatidylcholine:ceramide cholinephosphotransferase 1
    NP_001129861.2
    • Partially confirmed by transcript evidence
    NP_001255559.1
    • Partially confirmed by transcript evidence
    NP_502168.2
    • Partially confirmed by transcript evidence
    NP_502169.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11482662..11498174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069767.6 → NP_502168.2  Phosphatidylcholine:ceramide cholinephosphotransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502168.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3GWD9, H2L2K5, Q9U3D4, Q9XTV2
      Conserved Domains (2) summary
      pfam03247
      Location:17 → 121
      Prothymosin; Prothymosin/parathymosin family
      pfam14360
      Location:327 → 400
      PAP2_C; PAP2 superfamily C-terminal
    2. NM_069768.6 → NP_502169.2  Phosphatidylcholine:ceramide cholinephosphotransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502169.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U3D4
      Conserved Domains (2) summary
      pfam03247
      Location:6 → 81
      Prothymosin; Prothymosin/parathymosin family
      pfam14360
      Location:287 → 360
      PAP2_C; PAP2 superfamily C-terminal
    3. NM_001268630.3 → NP_001255559.1  Phosphatidylcholine:ceramide cholinephosphotransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255559.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L2K5
      Conserved Domains (2) summary
      pfam05793
      Location:1 → 128
      TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
      pfam14360
      Location:273 → 346
      PAP2_C; PAP2 superfamily C-terminal
    4. NM_001136389.4 → NP_001129861.2  Phosphatidylcholine:ceramide cholinephosphotransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129861.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U3D4
      Conserved Domains (1) summary
      pfam14360
      Location:210 → 283
      PAP2_C; PAP2 superfamily C-terminal
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