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    aho-3 Alpha/beta hydrolase domain-containing protein aho-3 [ Caenorhabditis elegans ]

    Gene ID: 172585, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aho-3
    Official Full Name
    Alpha/beta hydrolase domain-containing protein aho-3
    Primary source
    WormBase:WBGene00045192
    Locus tag
    CELE_K04G2.2
    See related
    AllianceGenome:WB:WBGene00045192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable palmitoyl-(protein) hydrolase activity. Involved in associative learning and behavioral response to starvation. Located in cytoplasmic vesicle and sensory dendrite. Is expressed in several structures, including AIY; amphid neurons; pharyngeal muscle cell; serotonergic neurons; and spermatheca. Orthologous to several human genes including ABHD17A (abhydrolase domain containing 17A, depalmitoylase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aho-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (8030959..8032880)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Eukaryotic translation initiation factor 2 subunit 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATPase family protein 2 homolog Neighboring gene SHSP domain-containing protein Neighboring gene palmitoyl-protein hydrolase Neighboring gene Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel and conserved protein AHO-3 is required for thermotactic plasticity associated with feeding states in Caenorhabditis elegans. Nishio N, et al. Genes Cells, 2012 May. PMID 22512337, Free PMC Article
    2. Genetic control of temperature preference in the nematode Caenorhabditis elegans. Mohri A, et al. Genetics, 2005 Mar. PMID 15654086, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in associative learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macromolecule depalmitoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sensory dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Alpha/beta hydrolase domain-containing protein aho-3
    NP_492210.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8030959..8032880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059809.8 → NP_492210.2  Alpha/beta hydrolase domain-containing protein aho-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492210.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21221
      Conserved Domains (1) summary
      COG1073
      Location:114 → 302
      FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21221.2

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