nck-1 NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nck-1
Official Full Name: NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family
Primary source: WormBase:WBGene00006410
Locus tag: CELE_ZK470.5
See related: AllianceGenome:WB:WBGene00006410
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Predicted to be involved in several processes, including ephrin receptor signaling pathway; positive regulation of translation in response to endoplasmic reticulum stress; and regulation of response to endoplasmic reticulum stress. Located in cytoplasm and nucleus. Is expressed in several structures, including egg-laying apparatus; gonad; hypodermis; nervous system; and neuroblasts. Orthologous to human NCK1 (NCK adaptor protein 1) and NCK2 (NCK adaptor protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nck-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 7

Sequence:: Chromosome: X; NC_003284.9 (4148648..4153443, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Caenorhabditis elegans nck-1 and filamentous actin-regulating protein pathway mediates a key cellular defense against bacterial pore-forming proteins.
Title: A Caenorhabditis elegans nck-1 and filamentous actin-regulating protein pathway mediates a key cellular defense against bacterial pore-forming proteins.
Data suggest that when MIG-38 is depleted, stimulation of a turning pathway is reduced, but MIG-15 could still couple with NCK-1 and promote distal tip cells (DTCs) motility.
Title: mig-38, a novel gene that regulates distal tip cell turning during gonadogenesis in C. elegans hermaphrodites.
Data show that NCK-1B is required for HSN cell migration while NCK-1A is required for efficient male mating.
Title: The C. elegans nck-1 gene encodes two isoforms and is required for neuronal guidance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK470.5 (e-PCR)
- UniSTS:313625

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of PERK-mediated unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translation in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family

NP_001361996.1

Product from WormBase gene class nck;
Confirmed by transcript evidence

NP_508706.2

Product from WormBase gene class nck;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4148648..4153443 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001375010.1 → NP_001361996.1 NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q95PX0
NM_076305.7 → NP_508706.2 NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508706.2

Status: REVIEWED

UniProtKB/TrEMBL

Q95PW9

Conserved Domains (4) summary

cd09943
Location:299 → 390

SH2_Nck_family; Src homology 2 (SH2) domain found in the Nck family

cd11765
Location:5 → 55

SH3_Nck_1; First Src Homology 3 domain of Nck adaptor proteins

cd11766
Location:118 → 171

SH3_Nck_2; Second Src Homology 3 domain of Nck adaptor proteins

cd11767
Location:215 → 270

SH3_Nck_3; Third Src Homology 3 domain of Nck adaptor proteins