cyd-1 G1/S-specific cyclin-D [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cyd-1
Official Full Name: G1/S-specific cyclin-D
Primary source: WormBase:WBGene00000870
Locus tag: CELE_Y38F1A.5
See related: AllianceGenome:WB:WBGene00000870
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including positive regulation of asymmetric protein localization involved in cell fate determination; positive regulation of brood size; and regulation of cell cycle process. Acts upstream of or within nematode male tail tip morphogenesis. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Is expressed in gonad; hypodermis; intestine; neurons; and vulva. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); endocrine gland cancer (multiple); hematologic cancer (multiple); and hepatitis B. Orthologous to several human genes including CCND3 (cyclin D3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cyd-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (12988223..12993112)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

fThe results suggest that certain mesodermal lineages may be uniquely affected by changes in cyd-1 activity.
Title: Cyclin D involvement demarcates a late transition in C. elegans embryogenesis.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y38F1A.5 (e-PCR)
- UniSTS:318781

STS2-205 (e-PCR)
- UniSTS:241880

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell cycle G1/S phase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gonadal mesoderm development	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of asymmetric protein localization involved in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of brood size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA endoreduplication	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell cycle G1/S phase transition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sex determination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G1/S-specific cyclin-D

NP_001369816.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

12988223..12993112

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383975.2 → NP_001369816.1 G1/S-specific cyclin-D [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O77085, Q9U2M5

Conserved Domains (1) summary

cd20515
Location:41 → 199

CYCLIN_CCND_rpt1; first cyclin box found in cyclin-D (CCND) family