him-3 HORMA domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: him-3
Official Full Name: HORMA domain-containing protein
Primary source: WormBase:WBGene00001862
Locus tag: CELE_ZK381.1
See related: AllianceGenome:WB:WBGene00001862
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA binding activity. Involved in regulation of centriole-centriole cohesion and synaptonemal complex assembly. Located in lateral element. Is expressed in oocyte and spermatocyte. Orthologous to human HORMAD1 (HORMA domain containing 1) and HORMAD2 (HORMA domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See him-3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 3

Sequence:: Chromosome: IV; NC_003282.8 (6977508..6978765)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans.
Title: Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK381.1 (e-PCR)
- UniSTS:307062

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in homologous chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of centriole-centriole cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sister chromatid cohesion	TAS Traceable Author Statement more info	PubMed
involved_in synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in lateral element	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: HORMA domain-containing protein

NP_501078.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6977508..6978765

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068677.7 → NP_501078.1 HORMA domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501078.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EBG0

Conserved Domains (1) summary

pfam02301
Location:50 → 233

HORMA; HORMA domain