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    smg-1 Serine/threonine-protein kinase smg-1 [ Caenorhabditis elegans ]

    Gene ID: 172418, updated on 9-Dec-2024

    Summary

    Official Symbol
    smg-1
    Official Full Name
    Serine/threonine-protein kinase smg-1
    Primary source
    WormBase:WBGene00004879
    Locus tag
    CELE_C48B6.6
    See related
    AllianceGenome:WB:WBGene00004879
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in male genitalia development and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be part of TOR complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See smg-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    42
    Sequence:
    Chromosome: I; NC_003279.8 (6900949..6913579, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Serpentine receptor class beta-15 Neighboring gene Essential protein Yae1 N-terminal domain-containing protein Neighboring gene U3 small nucleolar ribonucleoprotein imp3

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in male genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of TOR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Serine/threonine-protein kinase smg-1
    NP_001021053.1
    • Confirmed by transcript evidence
    NP_001361976.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6900949..6913579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025882.5NP_001021053.1  Serine/threonine-protein kinase smg-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021053.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01510, Q6BEW0, Q9U9U7
      Conserved Domains (3) summary
      cd05170
      Location:17512058
      PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
      pfam02260
      Location:22912321
      FATC; FATC domain
      pfam15785
      Location:468985
      SMG1; Serine/threonine-protein kinase smg-1
    2. NM_001374908.2NP_001361976.1  Serine/threonine-protein kinase smg-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      cd05170
      Location:17532060
      PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
      pfam02260
      Location:22932323
      FATC; FATC domain
      pfam15785
      Location:468984
      SMG1; Serine/threonine-protein kinase smg-1