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    mals-1 Mitochondrial Assembly of ribosomal Large Subunit [ Caenorhabditis elegans ]

    Gene ID: 176135, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mals-1
    Official Full Name
    Mitochondrial Assembly of ribosomal Large Subunit
    Primary source
    WormBase:WBGene00019677
    Locus tag
    CELE_K12H4.2
    See related
    AllianceGenome:WB:WBGene00019677
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ribosomal large subunit binding activity. Involved in IRE1-mediated unfolded protein response. Predicted to be active in mitochondrion. Orthologous to human MALSU1 (mitochondrial assembly of ribosomal large subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mals-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (8047712..8048464)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Signal peptidase complex subunit 3 Neighboring gene Ribosome biogenesis protein BRX1 homolog Neighboring gene Putative serine protease K12H4.7 Neighboring gene ncRNA Neighboring gene Homeobox protein prospero homolog 1 Neighboring gene ncRNA Neighboring gene tRNA-Pro

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in negative regulation of ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mitochondrial Assembly of ribosomal Large Subunit
    NP_498757.2
    • Confirmed by transcript evidence;
      Product from WormBase gene class mals

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8047712..8048464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066356.4 → NP_498757.2  Mitochondrial Assembly of ribosomal Large Subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498757.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34523
      Conserved Domains (1) summary
      pfam02410
      Location:65 → 167
      RsfS; Ribosomal silencing factor during starvation
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34523.2

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