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    Y65B4A.8 Cytidyltransferase-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171657, updated on 9-Dec-2024

    Summary

    Official Symbol
    Y65B4A.8
    Official Full Name
    Cytidyltransferase-like domain-containing protein
    Primary source
    WormBase:WBGene00022031
    Locus tag
    CELE_Y65B4A.8
    See related
    AllianceGenome:WB:WBGene00022031
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dephospho-CoA kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia type 12. Orthologous to human COASY (Coenzyme A synthase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See Y65B4A.8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (659565..663610, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Charged multivesicular body protein 6 Neighboring gene Peptidase C1A papain C-terminal domain-containing protein Neighboring gene LIM zinc-binding domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene Glycosyltransferase family 92 protein Neighboring gene choline-phosphate cytidylyltransferase

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dephospho-CoA kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dephospho-CoA kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Cytidyltransferase-like domain-containing protein
    NP_490766.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      659565..663610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058365.9NP_490766.2  Cytidyltransferase-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490766.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL56
      Conserved Domains (2) summary
      cd02164
      Location:102245
      PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
      cd02022
      Location:267444
      DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.