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    rpom-1 DNA-directed RNA polymerase [ Caenorhabditis elegans ]

    Gene ID: 173317, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rpom-1
    Official Full Name
    DNA-directed RNA polymerase
    Primary source
    WormBase:WBGene00013680
    Locus tag
    CELE_Y105E8A.23
    See related
    AllianceGenome:WB:WBGene00013680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-directed 5'-3' RNA polymerase activity and mitochondrial promoter sequence-specific DNA binding activity. Predicted to be involved in mitochondrial transcription. Predicted to be part of mitochondrial DNA-directed RNA polymerase complex. Is expressed in several structures, including germ line; intestine; nerve ring; oocyte; and vulva. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 55. Orthologous to human POLRMT (RNA polymerase mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rpom-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (14552030..14565853, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tight junction protein ZO-1 Neighboring gene ncRNA Neighboring gene DH domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial maturation drives germline stem cell differentiation in Caenorhabditis elegans. Charmpilas N, et al. Cell Death Differ, 2020 Feb. PMID 31217501, Free PMC Article
    2. ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription. Dai CY, et al. Nat Cell Biol, 2023 Aug. PMID 37460695
    3. Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response. Mao K, et al. PLoS Biol, 2020 Dec. PMID 33264285, Free PMC Article
    4. Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126). Schmitz C, et al. Proc Natl Acad Sci U S A, 2007 Jan 16. PMID 17213328, Free PMC Article
    5. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitochondrial promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial DNA-directed RNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase
    NP_001122531.1
    • Confirmed by transcript evidence
    NP_001122532.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14552030..14565853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129059.4 → NP_001122531.1  DNA-directed RNA polymerase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122531.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WQA3
      Conserved Domains (2) summary
      pfam00940
      Location:742 → 1137
      RNA_pol; DNA-dependent RNA polymerase
      pfam14700
      Location:512 → 601
      RPOL_N; DNA-directed RNA polymerase N-terminal

    2. NM_001129060.3 → NP_001122532.1  DNA-directed RNA polymerase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122532.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5PEY3
      Conserved Domains (2) summary
      pfam00940
      Location:742 → 1155
      RNA_pol; DNA-dependent RNA polymerase
      pfam14700
      Location:512 → 601
      RPOL_N; DNA-directed RNA polymerase N-terminal
    Nucleotide Protein
    Heading Accession and Version

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