stim-1 Stromal interaction molecule 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: stim-1
Official Full Name: Stromal interaction molecule 1
Primary source: WormBase:WBGene00021910
Locus tag: CELE_Y55B1BM.1
See related: AllianceGenome:WB:WBGene00021910
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calcium channel regulator activity and identical protein binding activity. Involved in several processes, including ovulation; positive regulation of engulfment of apoptotic cell; and store-operated calcium entry. Located in several cellular components, including dendrite; neuronal cell body; and plasma membrane. Is expressed in gonadal sheath cell; intestine; spermatheca; and uterine toroidal epithelial cell. Human ortholog(s) of this gene implicated in Stormorken syndrome; gastrointestinal system cancer (multiple); immunodeficiency 10; lung cancer; and tubular aggregate myopathy 1. Orthologous to several human genes including STIM1 (stromal interaction molecule 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See stim-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 12

Sequence:: Chromosome: III; NC_003281.10 (408126..418749, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we determined the X-ray crystal structure of the C. elegans STIM luminal domain, revealing that EF-SAM binds a single Ca(2+) ion with pentagonal bipyramidal geometry and an ancillary alpha-helix formed by the N-terminal region acts as a brace to stabilize EF-SAM.
Title: Coordination of a Single Calcium Ion in the EF-hand Maintains the Off State of the Stromal Interaction Molecule Luminal Domain.
Tyrosine316 may be involved in the auto-inhibitory mechanism of the STIM1 C-terminus in the quiescent state.
Title: An aromatic amino acid in the coiled-coil 1 domain plays a crucial role in the auto-inhibitory mechanism of STIM1.
Functional studies suggest that the inhibitory helix may keep the C-terminus of STIM1 in an inactive state.
Title: Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1).
This review describes the role of STIM1 in Ca(2+) release activated Ca(2+) (CRAC) channel activity in worm gonad and intestine.
Title: Physiological roles of STIM1 and Orai1 homologs and CRAC channels in the genetic model organism Caenorhabditis elegans.
This study characterizes STIM-1 function in an intact animal and suggests that store-operated Ca(2+) entry is not essential for certain oscillatory Ca(2+) signaling processes and for maintenance of store Ca(2+) levels in C. elegans.
Title: Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y55B1B_113.a (e-PCR)
- UniSTS:323115

Y55B1B_113.b (e-PCR)
- UniSTS:323116

Y55B1B_119.h (e-PCR)
- UniSTS:324095

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transport	IEA Inferred from Electronic Annotation more info
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info
involved_in store-operated calcium entry	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular organelle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Stromal interaction molecule 1

NP_001022916.1

Confirmed by transcript evidence

NP_741073.1

Confirmed by transcript evidence

NP_741074.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

408126..418749 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171065.6 → NP_741073.1 Stromal interaction molecule 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741073.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EF60

Conserved Domains (2) summary

pfam16533
Location:287 → 386

SOAR; STIM1 Orai1-activating region

cl15755
Location:109 → 182

SAM_superfamily; SAM (Sterile alpha motif )
NM_171858.6 → NP_741074.1 Stromal interaction molecule 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741074.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EF60, H2L0R4, H2L0R5

Conserved Domains (2) summary

pfam16533
Location:287 → 386

SOAR; STIM1 Orai1-activating region

cl15755
Location:109 → 182

SAM_superfamily; SAM (Sterile alpha motif )
NM_001027745.7 → NP_001022916.1 Stromal interaction molecule 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022916.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EF60

Conserved Domains (2) summary

pfam16533
Location:287 → 386

SOAR; STIM1 Orai1-activating region

cl15755
Location:109 → 182

SAM_superfamily; SAM (Sterile alpha motif )