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    phy-3 Fe2OG dioxygenase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 188624, updated on 9-Dec-2024

    Summary

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    Official Symbol
    phy-3
    Official Full Name
    Fe2OG dioxygenase domain-containing protein
    Primary source
    WormBase:WBGene00004026
    Locus tag
    CELE_T20B3.7
    See related
    AllianceGenome:WB:WBGene00004026
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in spermatheca. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See phy-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (16833165..16839141)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene Serpentine Receptor, class H Neighboring gene Troponin I 3 Neighboring gene C-type lectin domain-containing protein Neighboring gene pseudo Neighboring gene C-type lectin domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis. Myllyharju J. Matrix Biol, 2003 Mar. PMID 12714038
    2. Egg shell collagen formation in Caenorhabditis elegans involves a novel prolyl 4-hydroxylase expressed in spermatheca and embryos and possessing many unique properties. Riihimaa P, et al. J Biol Chem, 2002 May 17. PMID 11891226
    3. Characterization of a novel Caenorhabditis elegans prolyl 4-hydroxylase with a unique substrate specificity and restricted expression in the pharynx and excretory duct. Keskiaho K, et al. J Biol Chem, 2008 Apr 18. PMID 18276589
    4. The exoskeleton collagens in Caenorhabditis elegans are modified by prolyl 4-hydroxylases with unique combinations of subunits. Myllyharju J, et al. J Biol Chem, 2002 Aug 9. PMID 12036960
    5. Genetic interaction between Caenorhabditis elegans teneurin ten-1 and prolyl 4-hydroxylase phy-1 and their function in collagen IV-mediated basement membrane integrity during late elongation of the embryo. Topf U, et al. Mol Biol Cell, 2011 Sep. PMID 21795395, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fe2OG dioxygenase domain-containing protein
    NP_507251.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16833165..16839141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074850.3 → NP_507251.2  Fe2OG dioxygenase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507251.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUP0
      Conserved Domains (1) summary
      smart00702
      Location:102 → 277
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    Nucleotide Protein
    Heading Accession and Version

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