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    dhc-3 Dynein Heavy Chain [ Caenorhabditis elegans ]

    Gene ID: 179798, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhc-3
    Official Full Name
    Dynein Heavy Chain
    Primary source
    WormBase:WBGene00007154
    Locus tag
    CELE_B0365.7
    See related
    AllianceGenome:WB:WBGene00007154
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to be part of dynein complex. Predicted to be active in 9+2 motile cilium. Is expressed in HSN; lumbar right ganglion neurons; and outer labial neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhc-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    37
    Sequence:
    Chromosome: V; NC_003283.11 (13138981..13152466)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene C-type lectin domain-containing protein Neighboring gene Cubilin Neighboring gene Non-centrosomal microtubule array protein 1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Visualization of dynein-dependent microtubule gliding at the cell cortex: implications for spindle positioning. Gusnowski EM, et al. J Cell Biol, 2011 Aug 8. PMID 21825072, Free PMC Article
    2. A ZYG-12-dynein interaction at the nuclear envelope defines cytoskeletal architecture in the C. elegans gonad. Zhou K, et al. J Cell Biol, 2009 Jul 27. PMID 19635841, Free PMC Article
    3. Coupling of cortical dynein and G alpha proteins mediates spindle positioning in Caenorhabditis elegans. Nguyen-Ngoc T, et al. Nat Cell Biol, 2007 Nov. PMID 17922003
    4. NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. van der Voet M, et al. Nat Cell Biol, 2009 Mar. PMID 19219036
    5. Actin-dependent cytoplasmic streaming in C. elegans oogenesis. Wolke U, et al. Development, 2007 Jun. PMID 17507392

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We propose a model whereby different dynein-microtubule interactions are used for specific spindle-positioning tasks in the one-cell embryo.
      Title: Visualization of dynein-dependent microtubule gliding at the cell cortex: implications for spindle positioning.
    2. Results suggest that gonad architecture, including membrane and nuclear positioning, is determined by microtubule nucleation at the plasma membrane combined with tension on the microtubules by dynein anchored at the nucleus by ZYG-12.
      Title: A ZYG-12-dynein interaction at the nuclear envelope defines cytoskeletal architecture in the C. elegans gonad.
    3. ASPM-1, together with calmodulin (CMD-1), promotes meiotic spindle organization and the accumulation of LIN-5 at meiotic and mitotic spindle poles.
      Title: NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha.
    4. We established that microtubule dynamics and dynein are both required for generating efficient pulling forces and proper cell division to be achieved.
      Title: Coupling of cortical dynein and G alpha proteins mediates spindle positioning in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of inner dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Dynein Heavy Chain
    NP_506272.3
    • Product from WormBase gene class dhc;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13138981..13152466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073871.3 → NP_506272.3  Dynein Heavy Chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506272.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDV4
      Conserved Domains (2) summary
      pfam08393
      Location:629 → 1008
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2124 → 2429
      MT; Microtubule-binding stalk of dynein motor
    Nucleotide Protein
    Heading Accession and Version

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