nmrk-1 Molybdopterin synthase catalytic subunit [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nmrk-1
Official Full Name: Molybdopterin synthase catalytic subunit
Primary source: WormBase:WBGene00020842
Locus tag: CELE_T27A3.6
See related: AllianceGenome:WB:WBGene00020842
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable molybdopterin synthase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Predicted to be located in cytoplasm. Predicted to be part of molybdopterin synthase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type B. Orthologous to human MOCS2 (molybdenum cofactor synthesis 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nmrk-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (6105863..6107715, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T27A3.6 (e-PCR)
- UniSTS:311036

T27A3.7 (e-PCR)
- UniSTS:311037

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables molybdopterin synthase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in molybdopterin cofactor biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of molybdopterin synthase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Molybdopterin synthase catalytic subunit

NP_491763.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6105863..6107715 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059362.5 → NP_491763.1 Molybdopterin synthase catalytic subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491763.1

Status: REVIEWED

UniProtKB/TrEMBL

P91500

Conserved Domains (2) summary

cd00756
Location:205 → 332

MoaE; MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

cd02024
Location:8 → 163

NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...