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    ebax-1 SWIM-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177915, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ebax-1
    Official Full Name
    SWIM-type domain-containing protein
    Primary source
    WormBase:WBGene00004140
    Locus tag
    CELE_R09E10.7
    See related
    AllianceGenome:WB:WBGene00004140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables Hsp90 protein binding activity; misfolded protein binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of egg-laying behavior; positive regulation of miRNA catabolic process; and regulation of male mating behavior. Located in axon; cytosol; and neuronal cell body. Part of Cul2-RING ubiquitin ligase complex. Is expressed in excretory cell; nervous system; and vulval muscle. Orthologous to human ZSWIM8 (zinc finger SWIM-type containing 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ebax-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (10286955..10293013)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Thymidine kinase Neighboring gene DNA repair protein RAD51 homolog Neighboring gene PH domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamics of miRNA accumulation during C. elegans larval development. Nahar S, et al. Nucleic Acids Res, 2024 May 22. PMID 38381904, Free PMC Article
    2. Catalytic residues of microRNA Argonautes play a modest role in microRNA star strand destabilization in C. elegans. Kotagama K, et al. Nucleic Acids Res, 2024 May 22. PMID 38471816, Free PMC Article
    3. The developmentally timed decay of an essential microRNA family is seed-sequence dependent. Donnelly BF, et al. Cell Rep, 2022 Aug 9. PMID 35947946, Free PMC Article
    4. The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons. Wang Z, et al. Neuron, 2013 Sep 4. PMID 24012004, Free PMC Article
    5. Evolutionary and functional analysis of the invariant SWIM domain in the conserved Shu2/SWS1 protein family from Saccharomyces cerevisiae to Homo sapiens. Godin SK, et al. Genetics, 2015 Apr. PMID 25659377, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Hsp90 protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables misfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of miRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SWIM-type domain-containing protein
    NP_501888.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10286955..10293013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069487.7 → NP_501888.2  SWIM-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501888.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21875
    Nucleotide Protein
    Heading Accession and Version

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