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    F56D2.5 RBR-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

    Gene ID: 186378, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F56D2.5
    Official Full Name
    RBR-type E3 ubiquitin transferase
    Primary source
    WormBase:WBGene00018966
    Locus tag
    CELE_F56D2.5
    See related
    AllianceGenome:WB:WBGene00018966
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in innate immune response. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human RNF14 (ring finger protein 14). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F56D2.5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (5578414..5581419, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Nematode Specific Peptide family, group B Neighboring gene Uncharacterized protein Neighboring gene DUF4440 domain-containing protein Neighboring gene UBC core domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RBR-type E3 ubiquitin transferase
    NP_498196.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5578414..5581419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065795.5 → NP_498196.1  RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498196.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20871
      Conserved Domains (2) summary
      smart00591
      Location:10 → 133
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      smart00647
      Location:253 → 315
      IBR; In Between Ring fingers
    Nucleotide Protein
    Heading Accession and Version

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