ddl-2 WASH complex subunit homolog 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ddl-2
Official Full Name: WASH complex subunit homolog 1
Primary source: WormBase:WBGene00013000
Locus tag: CELE_Y48E1B.1
See related: AllianceGenome:WB:WBGene00013000
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable alpha-tubulin binding activity and gamma-tubulin binding activity. Involved in cytoplasmic sequestering of protein and determination of adult lifespan. Predicted to be located in cytosol. Predicted to be part of WASH complex. Predicted to be active in early endosome and recycling endosome. Is expressed in neurons. Orthologous to several human genes including WASHC1 (WASH complex subunit 1) and WASH2P (WASP family homolog 2, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ddl-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 3

Sequence:: Chromosome: II; NC_003280.10 (13541506..13547645, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that the proteins DDL-1 and DDL-2, previously implicated in life span extension, modulate HSF-1 activity by forming an inhibitory heterocomplex with HSF-1 and that formation of this complex is regulated by Insulin/IGF-1-like signaling.
Title: HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y48E1B.1 (e-PCR)
- UniSTS:322417

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-tubulin binding	IEA Inferred from Electronic Annotation more info
enables gamma-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic sequestering of protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of WASH complex	IBA Inferred from Biological aspect of Ancestor more info
part_of WASH complex	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WASH complex subunit homolog 1

NP_496847.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

13541506..13547645 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064446.5 → NP_496847.1 WASH complex subunit homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496847.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18195

Conserved Domains (1) summary

pfam11945
Location:2 → 283

WASH_WAHD; WAHD domain of WASH complex