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    epg-3 Ectopic P granules protein 3;Transmembrane protein 49 [ Caenorhabditis elegans ]

    Gene ID: 176712, updated on 9-Dec-2024

    Summary

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    Official Symbol
    epg-3
    Official Full Name
    Ectopic P granules protein 3;Transmembrane protein 49
    Primary source
    WormBase:WBGene00012559
    Locus tag
    CELE_Y37D8A.22
    See related
    AllianceGenome:WB:WBGene00012559
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in macroautophagy and negative regulation of autophagosome assembly. Located in cytoplasm. Is expressed in body wall musculature; intestine; and pharynx. Orthologous to human VMP1 (vacuole membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See epg-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (12934717..12942288)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Small ribosomal subunit protein uS10m Neighboring gene RRM domain-containing protein Neighboring gene Secreted protein Neighboring gene Glutamate decarboxylase;Glutamate decarboxylase 1 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Four metazoan autophagy genes regulate cargo recognition, autophagosome formation and autolysosomal degradation. Tian Y, et al. Autophagy, 2010 Oct. PMID 20814246
    2. C. elegans screen identifies autophagy genes specific to multicellular organisms. Tian Y, et al. Cell, 2010 Jun 11. PMID 20550938
    3. The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39. Manil-Ségalen M, et al. Dev Cell, 2014 Jan 13. PMID 24374177
    4. A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation. Swords SB, et al. Autophagy, 2024 Apr. PMID 37942902, Free PMC Article
    5. Nuclear hormone receptor NHR-49 acts in parallel with HIF-1 to promote hypoxia adaptation in Caenorhabditis elegans. Doering KRS, et al. Elife, 2022 Mar 14. PMID 35285794, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ectopic P granules protein 3;Transmembrane protein 49
    NP_001360486.1
    • Confirmed by transcript evidence
    NP_001360487.1
    • Confirmed by transcript evidence
    NP_001360488.1
    • Confirmed by transcript evidence
    NP_499688.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12934717..12942288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001372669.3 → NP_001360486.1  Transmembrane protein 49 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WWI5
      Conserved Domains (1) summary
      cl00429
      Location:257 → 313
      VTT; VMP1, TMEM41, and TVP38 (VTT) domain

    2. NM_067287.6 → NP_499688.2  Ectopic P granules protein 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499688.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XWU8
      Conserved Domains (1) summary
      cl00429
      Location:257 → 313
      SNARE_assoc; SNARE associated Golgi protein

    3. NM_001372671.1 → NP_001360487.1  Ectopic P granules protein 3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WXI6
      Conserved Domains (1) summary
      cl00429
      Location:220 → 276
      VTT; VMP1, TMEM41, and TVP38 (VTT) domain

    4. NM_001372670.2 → NP_001360488.1  Ectopic P granules protein 3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WTI5
      Conserved Domains (1) summary
      cl00429
      Location:220 → 276
      VTT; VMP1, TMEM41, and TVP38 (VTT) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XWU8.2

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