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    fre-1 NADPH-dependent diflavin oxidoreductase 1 [ Caenorhabditis elegans ]

    Gene ID: 180314, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fre-1
    Official Full Name
    NADPH-dependent diflavin oxidoreductase 1
    Primary source
    WormBase:WBGene00001485
    Locus tag
    CELE_Y113G7A.8
    See related
    AllianceGenome:WB:WBGene00001485
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable FMN binding activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity. Predicted to be involved in iron-sulfur cluster assembly. Located in nucleus. Is expressed in neurons and pharyngeal muscle cell. Orthologous to human NDOR1 (NADPH dependent diflavin oxidoreductase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fre-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (20075916..20087735, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene Homeobox protein ttx-1 Neighboring gene ncRNA Neighboring gene 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;m7GpppX diphosphatase Neighboring gene Protein transport protein SEC23 Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. Kwasnicka DA, et al. J Biol Chem, 2003 Oct 3. PMID 12871939, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADPH-dependent diflavin oxidoreductase 1
    NP_001294725.1
    • Confirmed by transcript evidence
    NP_507875.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20075916..20087735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075474.6 → NP_507875.1  NADPH-dependent diflavin oxidoreductase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507875.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGH9
      Conserved Domains (3) summary
      COG0369
      Location:3 → 584
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:5 → 142
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:210 → 584
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    2. NM_001307796.3 → NP_001294725.1  NADPH-dependent diflavin oxidoreductase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294725.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M1ZMI3
      Conserved Domains (3) summary
      COG0369
      Location:3 → 587
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:5 → 142
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:210 → 587
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    Nucleotide Protein
    Heading Accession and Version

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