pdk-1 3-phosphoinositide-dependent protein kinase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pdk-1
Official Full Name: 3-phosphoinositide-dependent protein kinase 1
Primary source: WormBase:WBGene00003965
Locus tag: CELE_H42K12.1
See related: AllianceGenome:WB:WBGene00003965
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein kinase activity. Involved in several processes, including cellular response to reactive oxygen species; dauer larval development; and regulation of synaptic assembly at neuromuscular junction. Located in axon; neuronal cell body; and nucleus. Is expressed in several structures, including gonad; intestine; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pdk-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 11

Sequence:: Chromosome: X; NC_003284.9 (1321344..1327986)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (PI3K)
Title: Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H33H01.a (e-PCR)
- UniSTS:322594

H42K12.2 (e-PCR)
- UniSTS:322205

H42K12.1 (e-PCR)
- UniSTS:314574

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity, acting on a protein	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to metal ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 3-phosphoinositide-dependent protein kinase 1

NP_001024742.1

Confirmed by transcript evidence

NP_001024743.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

1321344..1327986

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029572.4 → NP_001024743.1 3-phosphoinositide-dependent protein kinase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024743.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9UA36, Q9Y1J3

Conserved Domains (3) summary

smart00220
Location:69 → 364

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01262
Location:464 → 570

PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain

cd05581
Location:67 → 364

STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
NM_001029571.4 → NP_001024742.1 3-phosphoinositide-dependent protein kinase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024742.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9Y1J3

Conserved Domains (3) summary

smart00220
Location:69 → 362

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01262
Location:460 → 566

PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain

cd05581
Location:67 → 362

STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1