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    F52B11.2 putative phosphomannomutase [ Caenorhabditis elegans ]

    Gene ID: 178364, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F52B11.2
    Official Full Name
    putative phosphomannomutase
    Primary source
    WormBase:WBGene00009925
    Locus tag
    CELE_F52B11.2
    See related
    AllianceGenome:WB:WBGene00009925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphomannomutase activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation Ia. Orthologous to human PMM1 (phosphomannomutase 1) and PMM2 (phosphomannomutase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F52B11.2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (14083568..14084695)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene DBC1/CARP1 catalytically inactive NUDIX hydrolase domain-containing protein;SAP domain-containing protein Neighboring gene CXXC-type zinc finger protein 1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphomannomutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphomannomutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-mannose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in mannose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative phosphomannomutase
    NP_001255786.1
    • Confirmed by transcript evidence
    NP_001255787.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      14083568..14084695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268857.2 → NP_001255786.1  putative phosphomannomutase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255786.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E3W758, Q9XUE6
      Conserved Domains (2) summary
      TIGR01484
      Location:10 → 226
      HAD-SF-IIB; HAD-superfamily hydrolase, subfamily IIB
      pfam03332
      Location:31 → 252
      PMM; Eukaryotic phosphomannomutase

    2. NM_001268858.3 → NP_001255787.1  putative phosphomannomutase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255787.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XUE6
      Conserved Domains (2) summary
      COG0561
      Location:1 → 207
      Cof; Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only]
      pfam03332
      Location:2 → 223
      PMM; Eukaryotic phosphomannomutase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XUE6.2

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