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    npp-2 Nuclear pore complex protein Nup85 [ Caenorhabditis elegans ]

    Gene ID: 172611, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npp-2
    Official Full Name
    Nuclear pore complex protein Nup85
    Primary source
    WormBase:WBGene00003788
    Locus tag
    CELE_T01G9.4
    See related
    AllianceGenome:WB:WBGene00003788
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of nuclear pore. Involved in embryo development; nucleus organization; and protein localization to organelle. Part of nuclear pore. Human ortholog(s) of this gene implicated in nephrotic syndrome type 17. Orthologous to human NUP85 (nucleoporin 85). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npp-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (8291299..8293640, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene PHAF1 protein T01G9.2 Neighboring gene LRRCT domain-containing protein Neighboring gene Casein kinase II subunit beta Neighboring gene Meiotic spindle formation protein mei-1 Neighboring gene Anion exchange protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. X-chromosome silencing in the germline of C. elegans. Kelly WG, et al. Development, 2002 Jan. PMID 11807039, Free PMC Article
    2. mei-1, a gene required for meiotic spindle formation in Caenorhabditis elegans, is a member of a family of ATPases. Clark-Maguire S, et al. Genetics, 1994 Feb. PMID 8150281, Free PMC Article
    3. Dissection of the NUP107 nuclear pore subcomplex reveals a novel interaction with spindle assembly checkpoint protein MAD1 in Caenorhabditis elegans. Ródenas E, et al. Mol Biol Cell, 2012 Mar. PMID 22238360, Free PMC Article
    4. A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis. Roerink SF, et al. PLoS Genet, 2012 Jun. PMID 22761594, Free PMC Article
    5. Operons in C. elegans: polycistronic mRNA precursors are processed by trans-splicing of SL2 to downstream coding regions. Spieth J, et al. Cell, 1993 May 7. PMID 8098272

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of nuclear pore outer ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear pore complex protein Nup85
    NP_492256.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8291299..8293640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059855.7 → NP_492256.1  Nuclear pore complex protein Nup85 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492256.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22078
      Conserved Domains (1) summary
      pfam07575
      Location:35 → 559
      Nucleopor_Nup85; Nup85 Nucleoporin
    Nucleotide Protein
    Heading Accession and Version

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