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    smu-2 Smu-2 suppressor of mec-8 and unc-52 protein [ Caenorhabditis elegans ]

    Gene ID: 173693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smu-2
    Official Full Name
    Smu-2 suppressor of mec-8 and unc-52 protein
    Primary source
    WormBase:WBGene00004896
    Locus tag
    CELE_Y49F6B.4
    See related
    AllianceGenome:WB:WBGene00004896
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including mechanosensory behavior; nematode larval development; and regulation of alternative mRNA splicing, via spliceosome. Located in nucleolus. Is expressed widely. Orthologous to human IK (IK cytokine). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See smu-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (3482408..3490151)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene F-box associated domain-containing protein Neighboring gene BTB domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene RBR-type E3 ubiquitin transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural Basis for the Functional Coupling of the Alternative Splicing Factors Smu1 and RED. Ulrich AKC, et al. Structure, 2016 May 3. PMID 27150041
    2. Modular safe-harbor transgene insertion for targeted single-copy and extrachromosomal array integration in Caenorhabditis elegans. El Mouridi S, et al. G3 (Bethesda), 2022 Aug 25. PMID 35900171, Free PMC Article
    3. A genetic screen for suppressors of a mutated 5' splice site identifies factors associated with later steps of spliceosome assembly. Dassah M, et al. Genetics, 2009 Jul. PMID 19380478, Free PMC Article
    4. The mec-8 gene of Caenorhabditis elegans affects muscle and sensory neuron function and interacts with three other genes: unc-52, smu-1 and smu-2. Lundquist EA, et al. Genetics, 1994 Sep. PMID 8001796, Free PMC Article
    5. SMU-2 and SMU-1, Caenorhabditis elegans homologs of mammalian spliceosome-associated proteins RED and fSAP57, work together to affect splice site choice. Spartz AK, et al. Mol Cell Biol, 2004 Aug. PMID 15254247, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that loss-of-function mutations in the nonessential splicing factor smu-2 and smu-1 suppress unc-73 e936 uncoordination through changes in splicing.
      Title: A genetic screen for suppressors of a mutated 5' splice site identifies factors associated with later steps of spliceosome assembly.
    2. SMU-2 and SMU-1 function together to regulate splice site choice in the pre-mRNAs of unc-52 and other genes
      Title: SMU-2 and SMU-1, Caenorhabditis elegans homologs of mammalian spliceosome-associated proteins RED and fSAP57, work together to affect splice site choice.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mechanosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle organ morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Smu-2 suppressor of mec-8 and unc-52 protein
    NP_494559.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      3482408..3490151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062158.5 → NP_494559.1  Smu-2 suppressor of mec-8 and unc-52 protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494559.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N4U5
      Conserved Domains (2) summary
      pfam07807
      Location:428 → 530
      RED_C; RED-like protein C-terminal region
      pfam07808
      Location:72 → 290
      RED_N; RED-like protein N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N4U5.1

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