cwn-1 Protein Wnt-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cwn-1
Official Full Name: Protein Wnt-1
Primary source: WormBase:WBGene00000857
Locus tag: CELE_K10B4.6
See related: AllianceGenome:WB:WBGene00000857
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables receptor tyrosine kinase binding activity. Involved in several processes, including neuroblast migration; neuron migration; and positive regulation of axon guidance. Predicted to be located in cytoplasm; extracellular region; and plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including CAN; hypodermal cell; intestine; muscle cell; and somatic nervous system. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism. Orthologous to several human genes including WNT4 (Wnt family member 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cwn-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (130983..133598, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAB-5/Hox regulates the Q neuroblast transcriptome, including cwn-1/Wnt, to mediate posterior migration in Caenorhabditis elegans.
Title: MAB-5/Hox regulates the Q neuroblast transcriptome, including cwn-1/Wnt, to mediate posterior migration in Caenorhabditis elegans.
our results strongly suggest that functions of at least four Wnts (lin-44, cwn-1, cwn-2, and egl-20) determine the polarity orientation of seam cells
Title: Multiple Wnts redundantly control polarity orientation in Caenorhabditis elegans epithelial stem cells.
C. elegans Wnt homolog, cwn-1, functions to regulate asymmetric division of the ABpl/rpppa blast cell. Cwn-1 does not act alone in this process, and it functions with another redundant ligand that appears not to be a Wnt.
Title: CWN-1 functions with DSH-2 to regulate C. elegans asymmetric neuroblast division in a beta-catenin independent Wnt pathway.
Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border in C. elegans embryos
Title: Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border in C. elegans embryos.
CAM-1 interacts with and inhibits Egl-20, CWN-1 and MOM-2 during vulva morphogenesis.
Title: The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway.
Here, too, we found that four of five Wnt receptors can influence P7.p orientation, suggesting that a surprising amount of functional redundancy exists in Wnt signaling during C. elegans vulval induction.
Title: Multiple redundant Wnt signaling components function in two processes during C. elegans vulval development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K10B4.6 (e-PCR)
- UniSTS:311531

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables receptor ligand activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in generation of neurons	IEA Inferred from Electronic Annotation more info
involved_in interneuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in interneuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuroblast migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of anterior/posterior axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of motor neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of sensory neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info