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    adh-5 Alcohol dehydrogenase class-3 [ Caenorhabditis elegans ]

    Gene ID: 178597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    adh-5
    Official Full Name
    Alcohol dehydrogenase class-3
    Primary source
    WormBase:WBGene00019240
    Locus tag
    CELE_H24K24.3
    See related
    AllianceGenome:WB:WBGene00019240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity; alcohol dehydrogenase (NAD+) activity; and zinc ion binding activity. Predicted to be involved in formaldehyde catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in AMED syndrome; alcohol dependence; asthma; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See adh-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (911774..916315)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Flavin-containing monooxygenase Neighboring gene RRM domain-containing protein;tRNA (uracil(54)-C(5))-methyltransferase Neighboring gene DUF2428 domain-containing protein;Leucine-rich repeat-containing protein 29;Protein NLRC3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans contains genes encoding two new members of the Zn-containing alcohol dehydrogenase family. Glasner JD, et al. J Mol Evol, 1995 Jul. PMID 7608988
    2. Molecular evolution and functional divergence of alcohol dehydrogenases in animals, fungi and plants. Thompson CE, et al. Genet Mol Biol, 2018. PMID 29668010, Free PMC Article
    3. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables alcohol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in alcohol metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in formaldehyde catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Alcohol dehydrogenase class-3
    NP_001024016.1
    • Partially confirmed by transcript evidence
    NP_741507.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      911774..916315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028845.4 → NP_001024016.1  Alcohol dehydrogenase class-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024016.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17335
      Conserved Domains (2) summary
      cd08300
      Location:9 → 381
      alcohol_DH_class_III; class III alcohol dehydrogenases
      COG1062
      Location:9 → 383
      FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

    2. NM_171434.9 → NP_741507.1  Alcohol dehydrogenase class-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741507.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17335, Q8WSP4
      Conserved Domains (2) summary
      cd08300
      Location:9 → 379
      alcohol_DH_class_III; class III alcohol dehydrogenases
      COG1062
      Location:9 → 381
      FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17335.1

    Gene LinkOut

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