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    kynu-1 Kynureninase [ Caenorhabditis elegans ]

    Gene ID: 180883, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kynu-1
    Official Full Name
    Kynureninase
    Primary source
    WormBase:WBGene00015802
    Locus tag
    CELE_C15H9.7
    See related
    AllianceGenome:WB:WBGene00015802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable kynureninase activity. Predicted to be involved in anthranilate metabolic process and tryptophan catabolic process to kynurenine. Predicted to be active in cytoplasm. Is expressed in E lineage cell and hypodermal cell. Human ortholog(s) of this gene implicated in hydroxykynureninuria. Orthologous to human KYNU (kynureninase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kynu-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (6106927..6109338, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Transmembrane and coiled-coil domains protein 2 Neighboring gene ncRNA Neighboring gene UPAR/Ly6 domain-containing protein Neighboring gene Peroxisomal assembly protein PEX3 Neighboring gene 7TM GPCR serpentine receptor class x (Srx) domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutagen sensitivity of kynureninase mutants of the nematode Caenorhabditis elegans. Bhat SG, et al. Mol Gen Genet, 1980. PMID 6936603
    2. Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. van der Goot AT, et al. Proc Natl Acad Sci U S A, 2012 Sep 11. PMID 22927396, Free PMC Article
    3. Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity. Sutphin GL, et al. Aging Cell, 2017 Aug. PMID 28401650, Free PMC Article
    4. On the benefits of the tryptophan metabolite 3-hydroxyanthranilic acid in Caenorhabditis elegans and mouse aging. Dang H, et al. Nat Commun, 2023 Dec 14. PMID 38097593, Free PMC Article
    5. Cell-specific gene expression in the nematode. Klass MR. Int Rev Cytol, 1986. PMID 3533827

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kynureninase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kynureninase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-kynurenine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anthranilate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anthranilate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyridine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in quinolinate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan catabolic process to kynurenine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kynureninase
    NP_509023.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6106927..6109338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076622.8 → NP_509023.1  Kynureninase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509023.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18026
      Conserved Domains (1) summary
      TIGR01814
      Location:43 → 473
      kynureninase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18026.1

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