nsun-1 26S rRNA (cytosine-C(5))-methyltransferase nsun-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nsun-1
Official Full Name: 26S rRNA (cytosine-C(5))-methyltransferase nsun-1
Primary source: WormBase:WBGene00021073
Locus tag: CELE_W07E6.1
See related: AllianceGenome:WB:WBGene00021073
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables rRNA (cytosine-C5-)-methyltransferase activity. Involved in several processes, including negative regulation of cellular response to heat; negative regulation of locomotion involved in locomotory behavior; and positive regulation of egg-laying behavior. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed widely. Used to study Williams-Beuren syndrome. Orthologous to human NOP2 (NOP2 nucleolar protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nsun-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 9

Sequence:: Chromosome: II; NC_003280.10 (471262..475940, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ribosomal RNA m(5)C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans.
Title: The ribosomal RNA m(5)C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W07E6.1 (e-PCR)
- UniSTS:311153

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables S-adenosylmethionine-dependent methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables rRNA (cytosine-C5-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (cytosine-C5-)-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables rRNA (cytosine-C5-)-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA methylation	IEA Inferred from Electronic Annotation more info
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of LSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA base methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 26S rRNA (cytosine-C(5))-methyltransferase nsun-1

NP_001303796.1

Confirmed by transcript evidence

NP_493742.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

471262..475940 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061341.7 → NP_493742.1 26S rRNA (cytosine-C(5))-methyltransferase nsun-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493742.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0M7RDQ9, Q9TYV5

Conserved Domains (1) summary

COG0144
Location:153 → 508

RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
NM_001316867.3 → NP_001303796.1 26S rRNA (cytosine-C(5))-methyltransferase nsun-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0M7RDQ9

Conserved Domains (2) summary

TIGR00446
Location:2 → 255

nop2p; NOL1/NOP2/sun family putative RNA methylase

cl30717
Location:253 → 400

InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]