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    tftc-3 TPR_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179419, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tftc-3
    Official Full Name
    TPR_REGION domain-containing protein
    Primary source
    WormBase:WBGene00014114
    Locus tag
    CELE_ZK856.13
    See related
    AllianceGenome:WB:WBGene00014114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in transcription by RNA polymerase III. Predicted to be part of transcription factor TFIIIC complex. Orthologous to human GTF3C3 (general transcription factor IIIC subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tftc-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (10206716..10210344, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Ovule protein Neighboring gene DNA-directed RNA polymerase III subunit RPC8 Neighboring gene HIT-type domain-containing protein Neighboring gene Hypersensitive to pore-forming toxin protein 40

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Integral nuclear pore proteins bind to Pol III-transcribed genes and are required for Pol III transcript processing in C. elegans. Ikegami K, et al. Mol Cell, 2013 Sep 26. PMID 24011592, Free PMC Article
    2. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    3. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of transcription factor TFIIIC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TPR_REGION domain-containing protein
    NP_505626.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10206716..10210344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073225.6 → NP_505626.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505626.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95PV7
      Conserved Domains (2) summary
      sd00006
      Location:253 → 280
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:253 → 317
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version

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