aqp-3 Aquaporin-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: aqp-3
Official Full Name: Aquaporin-3
Primary source: WormBase:WBGene00000171
Locus tag: CELE_Y69E1A.7
See related: AllianceGenome:WB:WBGene00000171
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables water channel activity. Involved in glycerol transmembrane transport and water transport. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in excretory cell; intestine; and vas deferens. Orthologous to several human genes including AQP10 (aquaporin 10); AQP3 (aquaporin 3 (Gill blood group)); and AQP7 (aquaporin 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See aqp-3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (10961229..10966459, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Y69E1A.7 (e-PCR)
- UniSTS:317342

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables channel activity	IDA Inferred from Direct Assay more info	PubMed
enables channel activity	IEA Inferred from Electronic Annotation more info
enables glycerol channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in glycerol transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in polyol transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in water transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Aquaporin-3

NP_001293896.1

Confirmed by transcript evidence

NP_001309613.1

Confirmed by transcript evidence

NP_502044.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10961229..10966459 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069643.2 → NP_502044.1 Aquaporin-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502044.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XW36

Conserved Domains (1) summary

cd00333
Location:121 → 362

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
NM_001322776.4 → NP_001309613.1 Aquaporin-3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A131MBS2

Conserved Domains (1) summary

cd00333
Location:74 → 315

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
NM_001306967.3 → NP_001293896.1 Aquaporin-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293896.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061ADS9

Conserved Domains (1) summary

cl00200
Location:18 → 265

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...