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    ZC506.1 alpha-1,2-Mannosidase [ Caenorhabditis elegans ]

    Gene ID: 181210, updated on 9-Dec-2024

    Summary

    Official Symbol
    ZC506.1
    Official Full Name
    alpha-1,2-Mannosidase
    Primary source
    WormBase:WBGene00013919
    Locus tag
    CELE_ZC506.1
    See related
    AllianceGenome:WB:WBGene00013919
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; mannoprotein catabolic process; and ubiquitin-dependent glycoprotein ERAD pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including anal depressor muscle; coelomocyte; distal tip cell; egg-laying apparatus; and nervous system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ZC506.1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (9958960..9964747)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Cysteine synthase 1 Neighboring gene Phosphatidylserine synthase Neighboring gene G-protein coupled receptors family 3 profile domain-containing protein;putative metabotropic glutamate receptor mgl-1 Neighboring gene ncRNA

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in membrane  

    General protein information

    Preferred Names
    alpha-1,2-Mannosidase
    NP_509671.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9958960..9964747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077270.8NP_509671.3  alpha-1,2-Mannosidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509671.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q09641, Q09642
      Conserved Domains (2) summary
      cd02126
      Location:648772
      PA_EDEM3_like; PA_EDEM3_like: protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar ...
      pfam01532
      Location:36473
      Glyco_hydro_47; Glycosyl hydrolase family 47
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