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    pgp-4 P-GlycoProtein related [ Caenorhabditis elegans ]

    Gene ID: 181327, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pgp-4
    Official Full Name
    P-GlycoProtein related
    Primary source
    WormBase:WBGene00003998
    Locus tag
    CELE_F42E11.1
    See related
    AllianceGenome:WB:WBGene00003998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing and stress response to cadmium ion. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in body wall musculature; excretory cell; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pgp-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    16
    Sequence:
    Chromosome: X; NC_003284.9 (11357816..11364050)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Multidrug resistance protein pgp-3 Neighboring gene ncRNA Neighboring gene Protein tweety homolog 1 Neighboring gene Brp/Blh family beta-carotene 15,15'-monooxygenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The P-glycoprotein gene family of Caenorhabditis elegans. Cloning and characterization of genomic and complementary DNA sequences. Lincke CR, et al. J Mol Biol, 1992 Nov 20. PMID 1360540
    2. A P-glycoprotein protects Caenorhabditis elegans against natural toxins. Broeks A, et al. EMBO J, 1995 May 1. PMID 7743993, Free PMC Article
    3. The expression of two P-glycoprotein (pgp) genes in transgenic Caenorhabditis elegans is confined to intestinal cells. Lincke CR, et al. EMBO J, 1993 Apr. PMID 8096815, Free PMC Article
    4. Resistance to the macrocyclic lactone moxidectin is mediated in part by membrane transporter P-glycoproteins: Implications for control of drug resistant parasitic nematodes. Bygarski EE, et al. Int J Parasitol Drugs Drug Resist, 2014 Dec. PMID 25516824, Free PMC Article
    5. Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade. Kurz CL, et al. Biochem Biophys Res Commun, 2007 Nov 16. PMID 17888400, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables efflux transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to chemical IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    P-GlycoProtein related
    NP_001257142.1
    • Product from WormBase gene class pgp;
      Confirmed by transcript evidence
    NP_001257143.1
    • Product from WormBase gene class pgp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11357816..11364050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270214.5 → NP_001257143.1  P-GlycoProtein related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257143.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3KFS6
      Conserved Domains (3) summary
      cd03249
      Location:1027 → 1264
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:54 → 1262
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:51 → 324
      ABC_membrane; ABC transporter transmembrane region

    2. NM_001270213.3 → NP_001257142.1  P-GlycoProtein related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257142.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20331
      Conserved Domains (3) summary
      cd03249
      Location:1041 → 1278
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:68 → 1276
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:65 → 338
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version

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